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SN 2

CAS No. 823218-99-1

SN 2 ( CS-1190 )

Catalog No. M26454 CAS No. 823218-99-1

SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SN 2
  • Note
    Research use only, not for human use.
  • Brief Description
    SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.
  • Description
    SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.(In Vitro):Dominant negative TRPML3(D458K) was highly effective in eliminating SN 2-induced activity in epidermal melanocytes, suggesting that SN 2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN 2-responsive channel. SN 2 evoked TRPML3 responses, which at elevated concentrations was able to prompt a significant increase of the intracellular Ca2+ concentration.
  • Synonyms
    CS-1190
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    β-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    823218-99-1
  • Formula Weight
    255.4
  • Molecular Formula
    C17H21NO
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1cc(C)c(C2=NOC3C4CCC(C4)C23)c(C)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Marilyn P Law, et al. Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET? Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):174-85.
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